Hypercalcemia after the Discontinuation of Medroxyprogesterone Acetate
نویسندگان
چکیده
A 39-year-old woman was admitted to our hospital with symptoms of general fatigue, nausea, and vomiting that appeared three months after she stopped seven years of medroxyprogesterone acetate (MPA) medication for endometrial stromal sarcoma. Laboratory tests demonstrated moderate hypercalcemia. Several tests demonstrated that she was suffering from adrenal insufficiency. Glucocorticoid supplementation decreased her calcium level to a normal range, indicating that hypercalcemia was induced by adrenal insufficiency. It was suggested that she was suffering from MPA-induced adrenal insufficiency, but hypocortisolemia was being compensated by a high dose of MPA; hypocortisolemia and hypercalcemia then became evident after MPA treatment was discontinued.
منابع مشابه
P-157: A Comparison of The Effect of Levonorgestrel IUD with Oral Medroxyprogesterone Acetate on Abnormal Uterine Bleeding with Simple Endometrial Hyperplasia and Fertility Preservation
Background: Endometrial hyperplasia is important clinically, because it can lead to abnormal uterine bleeding (AUB) which itself can precede to endometrial cancer. Endometrial carcinoma is the most common malignancy of the female genital tract, occurring about 75-85% in younger, perimenopousal women as hyperplasic endometrial. The treatment is hysterectomy or hormone therapy with progesterone. ...
متن کاملDepot medroxyprogesterone acetate use in inner-city, minority adolescents: continuation rates and characteristics of long-term users.
OBJECTIVE To identify continuation rates of depot medroxyprogesterone acetate (Depo-Provera) and characteristics of long-term users in a population of inner-city, minority adolescents with high pregnancy rates. DESIGN Retrospective medical record review. SETTING An inner-city adolescent clinic and an adolescent pregnancy program. METHODS A review of the medical records of 250 females aged...
متن کاملLunelle monthly contraceptive injection (medroxyprogesterone acetate and estradiol cypionate injectable suspension): a contraceptive method for women in the US and worldwide.
This paper presents data from the first large US clinical trial of Lunelle monthly contraceptive injection, which is a combination of 25 mg of medroxyprogesterone acetate (MPA) and 5 mg of estradiol cypionate (E2C). The lead article reports that there was no occurrence of unintended pregnancies and no contraceptive discontinuation among more than 700 women using the MPA/E2C in a 60-week clinic...
متن کامل02 Contraception continuation rates.pmd
1Department of Public Health; 2Department of Epidemiology and Biostatistics, Faculty of Health, Zahedan Medical Sciences University, Zahedan, Islamic Republic of Iran. Received: 08/12/02; accepted: 13/05/03 ABSTRACT We evaluated contraception continuation rates and discontinuation reasons in Zahedan among 1741 women from 1998–2000. By Kaplan–Meier technique continuation rates were 92% for low d...
متن کاملDepot medroxyprogesterone acetate and bone mineral density in adolescents--the Black Box Warning: a Position Paper of the Society for Adolescent Medicine.
The purpose of this Position Paper is to review the published Black Box Warning regarding depot medroxyprogesterone acetate (DMPA) and bone loss as it relates to adolescent girls. The scientific findings that prompted the Food and Drug Administration to issue the warning are reviewed and the following additional issues are considered: (1) likely low risk of fracture related to DMPA use, (2) evi...
متن کامل